Vraylar (Cariprazine) Approved For Schizophrenia & Bipolar Disorder - Mental Health Daily (2023)

Vraylar (Cariprazine) was approved by the FDA on September 17, 2015 for the treatment of schizophrenia and mania associated with bipolar disorder. In clinical trials, the drug was referenced as “RGH-188” – containing Cariprazine as the primary active ingredient. The drug had completed Phase III clinical trials in 2012, and was pending FDA approval for several years prior to its recent 2015 approval.

While the drug shares commonalities with many already-approved atypical antipsychotics, it also has several mechanistic differences. Like other antipsychotics, it modulates the neurotransmission of dopamine at various receptors (e.g. D2 receptors) to prevent positive symptoms of schizophreniaand manic symptoms of bipolar disorder. Unlike many older antipsychotics, it acts primarily upon D3 receptors and is capable of amelioratingnegative symptoms of schizophreniawhen dopamine levels plummet.

Vraylar is the second atypical antipsychotic afterRexulti (Brexpiprazole) to get FDA approval in 2015. Rights to itsmanufacturing are owned by Gedeon Richter and Actavis. Though the drug is new, its side effect profile isn’t fully understood, and long-term effects remain unknown – it appears to be a promising new agentfor those whodon’t sufficiently respond to existing options.

How Vraylar (Cariprazine) Works (Mechanism of Action)

Vraylar’s mechanism of actiondiffers from otheratypical antipsychotics in that it primarily affects the D3 receptor as a partial agonist. Targeting the D3 receptor has been speculated to aid in modulation of dysfunctional transmission of dopamine, while reducing likelihood of certain side effects. Specifically, the likelihood of extrapyramidal effects may be slightly decreased when targeting D3 receptor sites due to their location within the ventral striatum (as opposed to the dorsal striatum).

  • D3 receptor partial agonist
  • D2 receptor partial agonist
  • 5-HT2B inverse agonist
  • 5-HT1A partial agonist

Like other atypical antipsychotics, Vraylar still significantly affects the D2 receptor as a partial agonist – but to a lesser extent than the D3 receptor. From a dopaminergic perspective, Vraylar is unique in that when an individual has high dopamine levels, the drug acts as an antagonist – inhibiting excessD3 and D2 receptor stimulation. On the other hand, when an individual has low dopamine levels, the drug acts as an agonist by actively stimulating the D3 and D2 receptors.

(Video) Vraylar (Cariprazine) For Schizophrenia And Bipolar Disorder (Medication Review)

The drugs antagonist effects on D3 and D2 receptors minimize likelihood of positive symptoms (hallucinations, delusions, etc.) and bipolar mania, whereas its agonist effects minimize probability of negative symptoms (blunted affect, psychomotor slowing, etc.) and depression. As a result of its broad spectrum of dopaminergic capabilities, a greater range of symptoms can be treated. In addition to Vraylar’s primarily dopaminergic effect, the drug also acts upon serotonin receptors.

Serotonergically, the drug targets 5-HT2B receptors as an inverse agonist – meaning it stimulates these receptors to generate the opposite effect of a traditional agonist. Vraylar also acts as a 5-HT1A partial agonist – which is thought to improve mood. Other receptors affected by Vraylar include: 5-HT2A (inverse agonist), 5-HT2C (inverse agonist), 5-HT7 (antagonist), and H1 (inverse agonist).

It is also important to note that the drug appears to occupy dopamine receptors based on the administered dosage. Monkey studies demonstratethat when administered at low doses, Vraylar may only occupy 5% of D2 and D3 receptors, whereas at high doses itcan occupy over 90% of these receptors. While both lowand highdoses can be effective for symptom management, it is apparent that higher doses may elicit greater therapeutic effects for certain individuals due to increased receptor occupancy.

  • Source: https://www.ncbi.nlm.nih.gov/pubmed/23320989
  • Source: https://www.ncbi.nlm.nih.gov/pubmed/21767587
  • Source: https://www.ncbi.nlm.nih.gov/pubmed/21625907
  • Source: https://www.ncbi.nlm.nih.gov/pubmed/21767587

Potential Benefits of Vraylar (Cariprazine)

There appear to be several benefits associated with using Vraylar for the treatment of schizophrenia and/or bipolar disorder. The biggest benefit to be derived from the drug is the modulation of dopamine and unique targeting of the D3 receptor (which may reduce some side effects). Additionally, the drug can treat a wide range of symptoms and improve outcomes among those with low or high levels of endogenous dopamine; it seems to modulate imbalances.

  • Adjunct: Vraylar is currently being investigated as an antidepressant augmentation strategy. Like most antipsychotics, it will likely be used as an adjuvant option for those who fail to get symptomatic relief from a first-line antidepressant such as an SSRI. It may be a particularly beneficial option for those with depression caused by low dopamine due to the fact that it agonizes D2 and D3 receptors. Furthermore, it may also be prescribed along with a mood stabilizer among those with bipolar disorder for synergistic symptomatic relief.
  • Efficacy: It is apparent that Vraylar is a clinically effective option for the treatment of schizophrenia and bipolar disorder. The drug has undergone rigorous preclinical and clinical testing and was found to be safe, well-tolerated, and effective throughout all stages of trials. Though it remains unclear as to how effective Vraylar is compared to other atypical antipsychotics, some speculate that it may exhibit greater efficacy due to its unique mechanism of action.
  • Mechanism of action: For those with dopaminergic dysfunction, a major potential advantage associated with Vraylar is its ability to modulate dopamine. If you have high dopamine, administration of Vraylar acts as an antagonist, minimizing excess stimulation at D3 and D2 receptor sites. If you have low dopamine, administration of Vraylar acts as an agonist, increasing stimulation at D3 and D2 receptor sites. Its ability to detect endogenous dopamine levels and correct imbalances is thought to provide significant benefit.
  • Multi-purpose: Unlike many antipsychotics and psychiatric medications, Vraylar is considered a multi-purpose medication in that it was approved by the FDA to treat both bipolar disorder and schizophrenia. Since it is also under investigation for the treatment of depression, it is important to consider that it may be effective for the treatment of a third psychiatric condition. The fact that it is a multi-purpose agent is advantageous in that it may provide significant benefit to those who struggle with multiple simultaneous mental illnesses (e.g. schizophrenia and major depression).
  • Pro-cognitive: Preliminary evidence from clinical trials suggests that Vraylar may enhance cognitive function. This means that the drug may ameliorate the highly-problematiccognitive symptoms of schizophrenia. Although it is unclear as to how Vraylar improves cognition, itspro-cognitive effect could bedue to its ability to modulate dopamine. An excess (high) or deficient (low) amount of dopamine is known to disrupt cognitive processes.
  • Side effects: Though Vraylar will likelyshare a similar side effect profile to other atypical antipsychotics (due to dopaminergic effects), its unique high affinity for the D3 receptor (in the ventral striatum) may minimize the intensity of certain extrapyramidal effects. It should also be considered that its affinity for the D3 receptor may improve tolerability for certain individuals.

Vraylar (Cariprazine) Clinical Trials: Schizophrenia & Bipolar Disorder

Vraylar (Cariprazine) has been tested extensively in both preclinical and clinical trials for the treatment of schizophrenia and bipolar disorder. It appears to be effective for treating both acute mania and mixed episodes (associated with bipolar 1 disorder) and a spectrum of symptoms associated with schizophrenia. Included below is a general synopsis of the published clinical trials investigating Cariprazine.

(Video) Cariprazine/Vraylar a D3 partial agonist for bipolar disorder and schizophrenia

2015: Schizophrenia Trial

Results from a Phase III clinical trial assessing the efficacy and safety of cariprazine were published in 2015. Individuals that were formally diagnosed with schizophrenia were assigned to receive either cariprazine (3 mg/d to 6 mg/d), cariprazine (6 mg/d to 9 mg/d), or a placebo over the course of 6 weeks. Prior to the administration of cariprazine (or placebo), the participants were assessed with the PANSS (Positive and Negative Syndrome Scale) and the CGI-S (Clinical Global Impressions Severity).

A total of 147 individuals had received the placebo, 151 individuals received the cariprazine between 3 mg/d and 6 mg/d, and 148 individuals received cariprazine 6 mg/d to 9 mg/d. Following 6 weeks of treatment, the individuals were reassessed with the PANSS and CGI-S. Results indicated that those receiving the cariprazine experienced significant symptomatic improvement compared to those receiving the placebo.

Researchers reported that the cariprazine was considered well-tolerated and effective for the treatment of schizophrenia. There was no significant differences between the group receiving cariprazine (3 mg/d to 6 mg/d) and the group receiving cariprazine (6 mg/d to 9 mg/d).

  • Source: http://www.ncbi.nlm.nih.gov/pubmed/26075487

2015: Bipolar I Disorder Trial

A study was published in 2015 documenting the efficacy, safety, and tolerability of both low and high dose cariprazine among those experiencing either acute mania or mixed episodes associated with type 1 bipolar disorder. Participants in the study were assigned at random to receive either: a placebo, cariprazine (3 mg/d to 6 mg/d), or cariprazine (6 mg/d to 12 mg/d) for a total of 3 weeks. At baseline, patients were assessed with the YMRS (Young Mania Rating Scale) and CGI-S (Clinical Global Impressions Severity).

Following 3 weeks of treatment, participants were reassessed with the YMRS and CGI-S to determine changes in symptom severity. Results indicated that both groups taking cariprazine improved significantly compared to a placebo – regardless of the dosing. Though more side effects were experienced with cariprazine than the placebo – the drug was considered well-tolerated.

(Video) Vraylar

Researchers concluded that administration of low dose cariprazine (3 mg/d to 6 mg/d) and high dose cariprazine (6 mg/d to 12 mg/d) are effective for the treatment of acute mania and mixed episodes among those with bipolar disorder.

  • Source: http://www.ncbi.nlm.nih.gov/pubmed/25562205

2014: Acute Exacerbation Schizophrenia

Results from a clinical trial published in 2014 documented the efficacy and safety of cariprazine among those with acute schizophrenia. This was a fixed-dose, double-blind, placebo-controlled study in which participants were assigned to receive either: a placebo, cariprazine at various doses (1.5 mg, 3 mg, 4.5 mg), or risperidone (4 mg). At pre-treatment baseline, participants were assessed for symptomatic severity with the PANSS and CGI-S.

Following 6 weeks of treatment, patients were reassessed with both the PANSS and CGI-S to determine whether symptoms had improved. Results indicated that those receiving the cariprazine (regardless of dose) and risperidone experienced clinically significant symptomatic improvement compared to individuals receiving the placebo. Since cariprazine was well-tolerated, this provides evidence that cariprazine is safe and effective among those with acute schizophrenia.

  • Source: http://www.ncbi.nlm.nih.gov/pubmed/24412468

Note: There are more clinical trials that just the few published above. These are some of the larger, more substantial trials that document its safety and efficacy. To get a better understanding of cariprazine, search the NCBI database.

Potential Drawbacks of Vraylar (Cariprazine)

When any new drug is approved, the general media and consumers automatically assume that it’s a utopian option compared to previously approved drugs. Although Vraylar may possess a unique mechanism of action, there is no reason to believe that it has superior efficacy or less side effects than other options. Those taking the drug will need to be aware of adverse reactions, potential long-term effects, and discontinuation symptoms.

(Video) VRAYLAR Review. What you must know! In depth personal experience. A MUST WATCH VIDEO.

  • Black box warning: Like all potent psychiatric drugs, it is likely that a black box warning will be attached to Vraylar. Any drug that is potent enough to treat symptoms of mania and schizophrenia is also potent enough to have detrimental effects in a subset of users. For this reason, it is important to be aware of the possibility that Vraylar could increase depression and suicidalityin certain individuals.
  • Dangers: Since this is a relatively new drug, the potential dangers associated with its use haven’t been fully elucidated. It could be relatively safe, but we could also end up seeing a lawyer commercial in a decade recruiting past-users for a lawsuit for those that were victim to adverse effects. All current-market antipsychotics should be considered dangerous psychiatric drugs due to the fact that their usage is associated with brain volume loss, weight gain, and creation of new health problems (e.g. Type 2 diabetes).
  • Efficacy: Though the drug was effective in clinical trials for the treatment of schizophrenia and bipolar disorder, it is unclear as to how its efficacy stacks up compared to other options. It is clearly more effective than a placebo, but is it any more effective than other, better-understood options? We don’t know. Furthermore, it is important to consider that from an individual perspective – this drug may not work at all. A percentage of users are likely to derive no benefit and/or feel worse from using this drug.
  • Side effects: Many people think that newer drugs always seem to have better side effect profiles. Although the targeting of the D3 receptor was thought to reduce the likelihood of extrapyramidal symptoms – they are still common with this drug. Other side effects associated with Vraylar include: anxiety, constipation, dizziness, insomnia, nausea, sedation, and vomiting.
  • Unknown long-term effects: Due to the fact that Vraylar is just hitting the market, we won’t fully understand its long-term effects for awhile. Unless some mad scientists figure out a way to accurately simulate the long-term effects of a new drug, the first users will serve as guinea pigs. Although Vraylar could have favorable long-term effects to other antipsychotics, it also could have more deleterious long-term effects; an important possibility to consider.
  • Withdrawal symptoms: All new drugs are marketed brilliantly and the creators attempt to persuade users that they won’t have any significant withdrawal symptoms. Any drug that elicits a broad spectrum of potent effects on dopaminergic and serotonergic systems will have troubling withdrawal symptoms. It is likely that the discontinuation symptoms associated with Vraylar will be as significant as those experienced when quitting any other antipsychotic.

Source: http://www.ncbi.nlm.nih.gov/pubmed/23320989

Would you try Vraylar (Cariprazine) for schizophrenia or bipolar disorder?

I’ve written about Cariprazine as a new schizophrenia medication, as well as a new bipolar medication. Personally I think the drug has a lot of promise in that it modulates the neurotransmission of dopamine, eliciting both antagonist effects and agonist effects based on detected endogenous levels of dopamine. In other words, the drug isn’t just automatically antagonizing or agonizing receptors for everybody – its effects are unique to the user’s neurotransmission.

Most antipsychotics do not attempt to modulate neurotransmission, rather they act a certain way regardless of endogenous dopamine levels. Vraylar is now the third FDA approved antipsychotic that acts as a dopamine receptor partial agonist (the other two include: Abilify and Rexulti). Vraylar differs from both Abilify and Rexulti though in that it is highly selective for the D3 receptor – which may offer some advantages.

Assuming you understand that Vraylar’s basic mechanism of action, would you consider using it to treat schizophrenia and bipolar disorder? Do you believe that the drug will turn out to be any safer and/or more effective than other antipsychotics? Share your thoughts on Vraylar in the comments section below.

Related Posts:

  • 3 New Bipolar Medications (2015): Drugs In Clinical Trials
  • Vraylar (Cariprazine) Withdrawal Symptoms: What To Expect After Discontinuation


Is Vraylar a strong antipsychotic? ›

4. Bottom Line. Vraylar is an atypical antipsychotic that is effective for the treatment of schizophrenia and bipolar disorder. Vraylar is usually well-tolerated and less likely than some other antipsychotics to cause elevations in blood sugar or total cholesterol levels, sedation, or weight gain.

What is Vraylar prescribed for? ›

VRAYLAR is a prescription medicine used in adults: along with antidepressant medicines to treat major depressive disorder (MDD) for short-term (acute) treatment of manic or mixed episodes that happen with bipolar I disorder. to treat depressive episodes that happen with bipolar I (bipolar depression)

Is Vraylar worth taking? ›

Most voted positive review. vraylar started working for me within the first week of being on it. improved my mood and felt positive about everything in general. have been taking it for about a month and it has helped more than anything i have taken. have not noticed any side affects either.

Why does Vraylar work so well? ›

Vraylar (Cariprazine) Is Approved as an Antidepressant 'Add On' The drug may help people with major depressive disorder who are taking an antidepressant but not improving. Cariprazine is thought to work by moderating levels of dopamine and serotonin in the brain.

Is Vraylar a happy pill? ›

Vraylar (cariprazine) is taken by mouth and used to improve mood, thoughts, and behaviors in adults who have schizophrenia or bipolar disorder. It's convenient because you only have to take it once a day. But it can put you at higher risk for uncontrolled body movements, compared with some similar medications.

Does Vraylar cause weight gain? ›

Patients taking VRAYLAR experienced changes in blood sugar and cholesterol similar to those who took a placebo. In 6-week and 8-week bipolar I depression studies, patients who took VRAYLAR experienced an average weight gain of 1.2 pounds, compared to those on placebo who lost 0.2 pounds.

What should I avoid while taking Vraylar? ›

You should avoid the consumption of grapefruit and grapefruit juice during treatment with cariprazine. Talk to your doctor or pharmacist if you have questions on this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs.

What are the mental side effects of Vraylar? ›

Some people who took Vraylar in studies reported insomnia (trouble sleeping), fatigue (low energy), and anxiety. It's important to note that these may also be symptoms of the conditions Vraylar is used to treat, such as bipolar depression in people with bipolar I disorder.

How fast does Vraylar work for bipolar? ›

It may take 8 weeks or longer before you feel the full effect of cariprazine. Cariprazine is usually taken once daily with or without food. Typically, patients begin at a low dose of medication and the dose is increased slowly over several weeks.

Will Vraylar give you energy? ›

Feeling sleepy

Vraylar use can cause people to feel sleepy or tired. In clinical trials, sleepiness was reported in 5% to 11% of people who took Vraylar, depending on the condition treated and dose taken. By comparison, sleepiness was reported in 4% to 6% of people who took a placebo.

How quickly does Vraylar start working? ›

How long does Vraylar take to work in patients with schizophrenia? Within the first 1-2 weeks hallucinations, disorganized thinking and delusions may improve. After 1-2 weeks patients may feel more motivated and have a greater desire to be around other people.

Is Vraylar like seroquel? ›

Official answer. Vraylar and Seroquel are both oral prescription medicines in a drug class called atypical antipsychotics. They are used to treat the mental health conditions schizophrenia and bipolar disorder. Vraylar is also approved to treat Major depressive disorder in adults.

How does it feel to be on Vraylar? ›

The most common side effects include difficulty moving or slow movements, tremors, uncontrolled body movements, restlessness and feeling like you need to move around, sleepiness, nausea, vomiting, and indigestion. These are not all possible side effects of VRAYLAR. Learn more about other possible side effects.

How sedating is Vraylar? ›

In clinical studies in patients being treated for schizophrenia, somnolence or sedation was reported in 5% to 10% of patients receiving Vraylar, and in 5% of those taking an inactive placebo. Drowsiness appears to occur more frequently with higher doses of Vraylar in patients with schizophrenia.

Is Vraylar better than other antipsychotics? ›

Advantages with Vraylar

Vraylar has a longer half-life and stays in your body longer so missing a dose or taking your dose late may not be as much of a problem as with other antipsychotics. This longer time in your body helps to stabilize blood levels with once-daily dosing.

Can Vraylar be addictive? ›

Vraylar has no habit-forming potential, but it is not recommended that you discontinue use of the drug before talking with your doctor, as withdrawal symptoms can occur.

What does Vraylar do to the brain? ›

Vraylar helps balance the levels of neurotransmitters in your brain. Neurotransmitters are chemicals that help your brain cells communicate with each other. The main neurotransmitters affected by Vraylar are dopamine and serotonin. Dopamine plays a role in causing hallucinations, delusions, and thought disorders.

What is the best bipolar medication? ›

Lithium: The first mood stabilizer for bipolar disorder. Mood stabilizers are medications that help control the highs and lows of bipolar disorder. They are the cornerstone of treatment, both for mania and depression. Lithium is the oldest and most well-known mood stabilizer and is highly effective for treating mania.

Does Vraylar suppress appetite? ›

Common Adverse Reactions (≥ 5% and at least twice the rate of placebo): extrapyramidal symptoms, akathisia, dyspepsia, vomiting, somnolence, and restlessness.
Patients With Bipolar Mania.
System Organ Class / Preferred TermDecreased appetite
Placebo (N= 442) (%)3
39 more columns

Can Vraylar make you angry? ›

In some people, Vraylar can cause irritation, agitation and aggressive or abnormal behaviour. Similar to many antipsychotic drugs, Vraylar can make people have suicidal thoughts and increase the risk of developing depression. In simple words, yes, this medication can cause anger in some patients.

Does Vraylar affect sleep? ›

Insomnia is a possible side effect of taking Vraylar. Insomnia is a condition in which you have difficulty sleeping. People who took Vraylar reported symptoms such as: difficulty falling asleep or staying asleep.

Can Vraylar cause brain fog? ›

For Major Depressive Disorder "I've taken Vraylar for two weeks and it has been a very unpleasant experience for me. It has been an add-on to Trintellix that I take for depression. I've experienced a number of side effects including weight gain, insomnia, drowsiness, and brain fog, lots of brain fog.

Does Vraylar affect memory? ›

Antipsychotic medications like Vraylar can raise the risk of stroke and death in elderly patients who have lost touch with reality (psychosis) due to confusion and memory loss (dementia).

Is memory loss a side effect of Vraylar? ›

Medicines like VRAYLAR can raise the risk of death in elderly who have lost touch with reality (psychosis) due to confusion and memory loss (dementia). VRAYLAR is not approved for the treatment of patients with dementia-related psychosis. Increased risk of suicidal thoughts and actions.

Should I take Vraylar at night or in the morning? ›

Even though Vraylar may be taken at any time of the day, some people may find that changing the time of day that you take Vraylar helps with certain side effects. For example, people who experience restlessness or restless legs as a side effect of Vraylar may find taking it in the morning helps.

What is the safest antipsychotic drug? ›

Clozapine and olanzapine have the safest therapeutic effect, while the side effect of neutropenia must be controlled by 3 weekly blood controls. If schizophrenia has remitted and if patients show a good compliance, the adverse effects can be controlled.

Is Vraylar the same as lithium? ›

Vraylar and Eskalith (Lithium) belong to different drug classes. Vraylar is an atypical antipsychotic and Eskalith (Lithium) is an antimanic agent. Side effects of Vraylar and Eskalith (Lithium) that are similar include vomiting, sleepiness/drowsiness, and diarrhea.

Is Vraylar good for schizophrenia? ›

VRAYLAR is approved in adults for the treatment of schizophrenia. VRAYLAR and antidepressants may increase suicidal thoughts or actions in some children and young adults especially within the first few months of treatment or when the dose is changed.

Is Vraylar a mood stabilizer or antipsychotic? ›

Generic Name: cariprazine

Cariprazine is used to help treat certain mental/mood disorders (such as bipolar disorder, depression, schizophrenia). Cariprazine belongs to a class of drugs known as atypical antipsychotics.

What is the most successful antipsychotic? ›

Apart from clozapine, the following two drugs—aripiprazole and paliperidone—have been shown to be most effective, whereas quetiapine, ziprasidone and haloperidol displayed a relatively short time to discontinuation.

Can Vraylar treat anxiety and depression? ›

No, Vraylar is not used to treat anxiety disorders. It's also not used to treat borderline personality disorder. The Food and Drug Administration (FDA) has not approved this drug to treat these conditions. Vraylar is approved to treat mixed or manic episodes of bipolar I disorder.

What is the strongest antipsychotic drug? ›

Clozapine, which has the strongest antipsychotic effect, can cause neutropenia.

What is the most potent typical antipsychotic? ›

highfluphenazine and haloperidol
middleperphenazine and loxapine

What are the strengths of Vraylar? ›

Vraylar comes in four strengths: 1.5 milligrams (mg) 3 mg. 4.5 mg.

What is the best drug for schizophrenia? ›

Newer medications, called atypical antipsychotics, are also effective in relieving the symptoms of schizophrenia. These medications, including quetiapine, risperidone, and aripiprazole, are generally prescribed because they pose a lower risk of certain serious side effects than conventional antipsychotics.

What is the most commonly abused antipsychotic? ›

Quetiapine abuse is relatively common, and is abused far more often than any other second-generation antipsychotic.

Which anti psychotic is the weakest? ›

Chlorpromazine is a low potency antipsychotic which is used with psychosis, schizophrenia and manic episodes. This drug has the side effect of hypotension and also has anti-histamine properties, which counteract the extrapyramidal symptoms experienced with antipsychotics.

Is Vraylar the same as Seroquel? ›

Vraylar is more expensive than generic Seroquel. A generic option for Vraylar has not yet been marketed in the U.S. Vraylar is only approved by the FDA to be used in adults, while Seroquel can also be used for children and adolescents for certain conditions.

What can you not take with Vraylar? ›

You should avoid the consumption of grapefruit and grapefruit juice during treatment with cariprazine. Talk to your doctor or pharmacist if you have questions on this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs.

What is the new medicine for schizophrenia? ›

But a new drug is bringing hope to the field. Xanomeline-trospium, or KarXT, has a novel way of diminishing dopamine transmission that's showing promise at reducing symptoms while also limiting side effects.

What is the fastest working antipsychotic? ›

Drugs with the fastest onsets include haloperidol, risperidone, and olanzapine, with onsets appearing in 2 6 days. Chlorpromazine and thiothixene were at the slowest end of the continuum, with onsets of 2 weeks or longer.

What is the most sedating antipsychotic? ›

The more sedating ones, such as clozapine, olanzapine, quetiapine, and ziprasidone, are less likely to cause akathisia. When patients cannot tolerate either of these side effects, brexpiprazole and iloperidone are good options, with number needed to harm (NNH) above 30 for both sedation and akathisia.


1. Cariprazine: new FDA Indication for Depression (MDD) Augmentation
(Psychiatry Education Forum)
2. Cariprazine Aims to Further Antipsychotic Market for Mental Health
3. Treatment of Schizophrenia and Bipolar Disorder: Focus on Cariprazine
(Live Webinar)
4. Vraylar (cariprazine)- Schizophrenia- by Saro Arakelians, PharmD- Episode # 90
(Pharmacist Education Corner- by Saro Arakelians)
5. Cariprazine (Vraylar)
6. Cariprazine, brexpiprazole and lurasidone use in depression.
(Alessandro Serretti)


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