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04 - 10
2018
4 Commentaires par :eric dans :Biochimie/Métabolisme,
Se pourrait-il que les athlètes accumulent davantage de muscles à long terme s’ils prenaient quelques grammes de N-acétylglucosamine chaque jour. C’est une hypothèse que nous formulons avec prudence car il s’agit principalement d’une recherche in vitro. Mais ensuite, une étude animale avec des souris atteintes de dystrophie musculaire a été réalisée par des chercheurs canadiens…
Le N-acétylglucosamine
Si vous liez un groupe acétyle à une molécule de glucosamine, vous obtenez de la N-acétylglucosamine. Le corps fabrique ce métabolite en métabolisant la glucosamine par acétylation, mais les scientifiques pensent que seule une fraction de la glucosamine administrée par voie orale est convertie en N-acétylglucosamine. C’est pour cette raison que les fabricants de suppléments, en plus de la glucosamine, commercialisent également la N-acétylglucosamine.
Ces suppléments seraient destinés à rendre les articulations plus saines. La glucosamine et la N-acétylglucosamine sont les matières premières de l’acide hyaluronique, un polymère important du liquide synovial des articulations.
Des chercheurs de l’Université de Laval au Canada pensent que la N-acétylglucosamine jouerait également un rôle dans le développement musculaire. Lorsque les jeunes cellules musculaires forment des fibres musculaires, elles utilisent la N-acétylglucosamine comme un fixant pour se lier entre elles. Cela pourrait signifier que la supplémentation en N-acétylglucosamine présente un effet de renforcement musculaire.
Ajoutons que même en dehors du sport, déterminer de nouvelles ressources moléculaires potentielles en matière de renforcement musculaire suscite un vif intérêt scientifique. Comme bien d’autres, des chercheurs comme les Canadiens de la faculté de Laval cherchent avec détermination de nouveaux moyens de ralentir les maladies liées aux muscles comme la maladie de Duchenne. Les Canadiens se sont alors demandés: la N-acétylglucosamine pourrait-elle être une molécule à effets thérapeutiques ?
L’étude in vitro sur cette forme de glucosamine
Les chercheurs ont placé de jeunes cellules musculaires dans un tube à essai avec différentes concentrations de N-acétylglucosamine pendant 72 heures. Celle-ci a accéléré le processus.
Le tableau ci-dessus suggère que la concentration optimale du métabolite de la glucosamine serait certainement d’un millimole. C’est une valeur a priori élevée. Ci-dessous, vous pouvez constater les effets de la molécule à cette concentration au cours des 72 heures de l’expérience.
L’étude animale avec le N-acétylglucosamine
Les chercheurs ont donné à de jeunes souris de type mdx – des souris atteintes de la maladie de Duchenne – une dose quotidienne élevée de N-acétylglucosamine pendant 10 jours. Si les souris avaient été des êtres humains adultes, on leur aurait administré 3 à 4 grammes de la molécule par jour. Après la supplémentation, les chercheurs ont comparé les muscles des animaux à ceux de souris mdx ne l’ayant pas reçu.
Le supplément avait réduit les dommages musculaires et renforcé leurs muscles. Les chercheurs avaient stimulé les muscles électriquement et déterminé le poids que les muscles pouvaient mettre en mouvement.
Conclusion sur l’influence de la glucosamine acétylée et l’hypertrophie musculaire
«Nous présentons ici la preuve que […] la N-acétylglucosamine, […] [présente] un potentiel thérapeutique intéressant pour atténuer certains symptômes associés à la dystrophie musculaire de Duchenne», écrivent les Canadiens. «La présente étude suggère le potentiel thérapeutique d’un traitement à court terme avec la N-acétyl-glucosamine lors du pic de dégénérescence et de régénération musculaire chez la souris mdx. Cependant, il reste à déterminer si un traitement à long terme avec cette forme de glucosamine atténue de façon continue la progression de la dystrophie musculaire de Duchenne.»
«Bien que d’autres études soient essentielles pour comprendre le mécanisme par lequel […] la N-acétyl-glucosamine atténue la dystrophie musculaire de Duchenne […] et favorise la myogenèse, la présente étude indique que l’utilisation de la molécule en tant qu’agent supplémentaire peut présenter une classe intéressante de traitement contre la dystrophie musculaire de Duchenne. Notamment parce que la sécurité de ce monosaccharide bon marché est relativement bien établie chez l’homme.»
Source de l’article: N-acetylglucosamine accelerates the formation of muscle fibres
Source Ergo-log: FASEB J. 2018 Jun 12:fj201701151RRR. [Epub ahead of print].
Traduction pour Espace Corps Esprit Forme
Eric Mallet
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Eric
A propos de l'auteur
Passionné et pratiquant de la musculation depuis près de 28 ans, je me suis toujours intéressé au développement des ergogènes et de la nutrition sportive. Diplômé des universités Lille 3 et Paris 7, je travaille actuellement sur la rédaction de plusieurs ouvrages dont la sublimation par la culture physique et la musculation sur le plan psychanalytique. Consultant dans le domaine des compléments alimentaires, j'accompagne les entreprises dans le développement de leur stratégie de vente et de communication en matière de nutrition sportive.Espace Corps Esprit Forme est à considérer comme un blog de vulgarisation scientifique, destiné à aider les athlètes tout en leurs donnant des informations scientifiques utiles à leur pratique des sports de force.
4 Commentaires
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Sylar -6 octobre 2018 - 17 h 03 min
Salut Eric,
Sais-tu si cette N-acétylglucosamine a le même effet indésirable que la Glucosamine (HCL et sulfate) à savoir une hypertension oculaire ?!
J’ai pris pendant quelques mois de la glucosamine pour soigner une articulation douloureuse, au niveau douleur ça a été plutôt efficace mais mon opthalmo n’a pas aimé du tout !
A la visite annuelle j’ai eu droit à une grosse frayeur, alors que je n’avais jamais eu de tension anormale aux yeux, là il me prédisait d’emblée un glaucome avec sévères suites vu l’ampleur de la tension.
Finalement j’ai passé toute une batterie d’examens oculaires qui n’ont absolument rien démontré et ce n’est qu’après des recherches extrêmement ciblées que j’ai découvert que cela venait de la glucosamine, ce qu’a confirmé l’ophtalmo qui n’avait pas pensé à me demander si j’en prenais…
Bref, je profite de cet article pour te poser la question ;)
@+ et encore merci pour ce site et tous tes articles :)
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Eric -6 octobre 2018 - 18 h 52 min
Salut et merci pour ta question,
A vrai dire, même s’il s’agit d’une autre molécule (car acétylée), la glucosamine n’est reste pas moins composée en partie de glucose. En ce qui concerne les études cliniques effectuées à ce sujet, les résultats sont mitigés: https://www.sciencedirect.com/science/article/pii/S1063458411000203 A ce sujet, une hypothèse est souvent avancée, celle de la glucosamine comme précurseur des glucosaminoglycanes, une famille de molécules (dont le sulfate de chondroÎtine) pourrait être responsable d’une hypertension oculaire. Cependant, rien n’est certain à ce sujet. L’hypertension oculaire est réversible. Donc, par prudence, abstiens-toi de prendre de la glucosamine.
Quoi qu’il en soit, je m’étonne toujours de la crainte des athlètes ou des sédentaires face à une inflammation comme la tendinite. Cette crainte est souvent disproportionnée et donne souvent lieu à une supplémentation parfois exagérée face à ce genre de trouble passager et rarement chronique. Il est vrai qu’une tendinite est souvent longue à soigner et demande parfois 6 à 12 semaines avant de se résorber. Avec un peu de bon sens, une bonne crème (chauffante ou cryo) appliquée quotidiennement constitue souvent le premier des remèdes, avec du repos.
@ bientôt,
Erichttps://www.espacecorps-espritforme.fr/
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Sylar -6 octobre 2018 - 21 h 09 min
OK merci Eric pour cette réponse rapide :)
Par contre je n’ai pas compris pourquoi tu me parles de tendinite…
En ce qui me concerne c’est une usure prématurée d’un cartilage au genou qui m’a poussé à prendre un cocktail Glucosamine HCL + Chondroïtine sulfate + MSM et j’ai véritablement constaté une nette amélioration.
Mon genou craquait assez sévèrement et rien qu’en marchant avant le traitement alors qu’aujourd’hui il ne craque que quand je pose le genou à terre et la douleur associée a disparue.
Après, à savoir si c’est le cocktail qui a fonctionné, un seul voir deux de ces composants ou si c’est l’effet placébo… Qui vivra verra :D
MErci encore
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Eric -6 octobre 2018 - 21 h 46 min
> Ta question était basée sur une inflammation articulaire avec comme effet secondaire une hypertension oculaire, je t’ai donc répondu en ce sens. Les tendinites font partie des inflammations de ce type, parmi d’autres. Te concernant, il est probable que la glucosamine/chondroïtine/MSMS puisse contribuer à la réparation de ton cartilage. Cependant, si une hypertension oculaire se pose effectivement, il serait plus raisonnable de cesser ce genre de supplémentation. La glucosamine est à la base des glucosaminoglycanes, la chondroïtine en est le type le plus fréquent. Si tu prends de la glucosamine, ton organisme synthétisera de la chondroïtine. Donc, abstiens-toi de prendre les deux. Le silicium organique, le MSM ou le collagène, voire le cissus quadrangularis seraient plus indiqués dans ce cas.
Eric
https://www.espacecorps-espritforme.fr/
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FAQs
What is the function of N acetylgalactosamine? ›
The amino sugar N-acetylglucosamine (GlcNAc) is well known for the important structural roles that it plays at the cell surface. It is a key component of bacterial cell wall peptidoglycan, fungal cell wall chitin, and the extracellular matrix of animal cells.
What is N acetyl glucosamine good for? ›N-acetyl glucosamine is taken for osteoarthritis and inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease.
What are the side effects of N acetyl glucosamine? ›N-acetyl glucosamine is also possibly safe when used for up to 6 months. Glucosamine can cause some mild side effects including bloating, nausea, diarrhea, and constipation.
Is N acetyl glucosamine a protein? ›N-Acetyl glucosamine (NAG) is an amino sugar precursor in the human skin of the high molecular weight, water-binding polymer hyaluronic acid.
Is N acetyl BD glucosamine a reducing sugar? ›N-acetyl-Я-D-glucosamine is a reducing sugar because it contains a free anomeric carbon at C-1 that can open to the straight-chain form and therefore can be oxidized.
What blood type has N-acetylglucosamine? ›There are four common blood groups in the ABO system: O, A, B, and AB. The blood groups are defined by the presence of specific carbohydrate sugars on the surface of red blood cells, N-acetylgalactosamine for the A antigen, and D-galactose for the B antigen.
Is it OK to take glucosamine everyday? ›It is OK to take glucosamine every day, but check with your healthcare provider. For example, with osteoarthritis, the following doses have been studied: By mouth: 1,500 milligrams (mg) per day, taken either at once, in two doses of 750 mg, or in three doses of 500 mg.
Is NAC supplement good for arthritis? ›According to experimental and tissue culture studies, NAC is effective in clearing free-oxygen radicals, slowing the cartilage degradation process, reducing synovial inflammation, and reducing pain.
Who should not take glucosamine? ›Glucosamine may also increase glaucoma risk. Therefore, it shouldn't be taken by those at risk of developing glaucoma, including those with a family history of glaucoma, people ages 60 or older, and those who have diabetes, heart disease, or high blood pressure ( 31 ).
Does NAC give you energy? ›Dietary NAC did not affect energy status but enhanced the hepatic antioxidant capacity by increasing the activities of antioxidant enzymes in cold-stressed broilers.
Is hair loss a side effect of glucosamine? ›
...
Common side effects of chondroitin and glucosamine may include:
- nausea, diarrhea, constipation;
- stomach pain, gas, bloating;
- hair loss; or.
- puffy eyelids.
N-acetylglucosamine (GlcNAc), a glucosamine (GlcN) derivative, has been developed as an immunomodulatory and anti-inflammatory inexpensive and non-toxic drug for non-communicable disease treatment and/or prevention.
What is the difference between N-acetyl glucosamine and glucosamine? ›N-acetyl-glucosamine (NAG) is a form of glucosamine, one of the building blocks of joint tissue and other connective tissues. NAG differs from glucosamine sulfate and glucosamine hydrochloride; instead of a sulfur or chloride molecule, NAG has a larger, more complex molecule attached to it.
What is the difference between N-acetyl glucosamine and N-acetyl-D-glucosamine? ›The key difference between N-acetyl-D-glucosamine and N-acetyl glucosamine is that N-acetyl-D-glucosamine is the D isomer of N-acetyl glucosamine, whereas N-acetyl glucosamine is an amide that occurs as a major component in the bacterial cell wall. N-acetyl glucosamine is an important amide compound.
What is an alternative to N-acetyl glucosamine? ›Panthenol would be a decent alternative as it plays many similar roles. Otherwise you could replace N-Acetyl Glucosamine (NAG) with a humectant, like glycerine or sodium lactate, or just use more water. Add it to the cool-down phase of your recipe.
Does glucosamine raise a1c? ›Taking glucosamine may not affect blood glucose levels directly, but some evidence from both animal and human studies suggests that it may promote insulin resistance over time.
Why can't diabetics take glucosamine? ›(4) Several animal and in vitro studies have shown that high doses of glucosamine can induce insulin resistance and raise plasma level of glucose.
What foods contain N acetylglucosamine? ›What foods are high in glucosamine? Food sources of glucosamine are few and far between. The only natural food sources are shellfish shells from shrimp, lobster and crabs. It's these shells that are harvested and used to make the synthetic version of glucosamine that goes into the supplements that are made in labs.
Is N-acetylglucosamine natural? ›N-acetylglucosamine (NAG) is a naturally occurring amino sugar and can be used as a precursor for epithelial glycosaminoglycan synthesis.
What is the rarest O blood type? ›Only 7% of the population are O negative. However, the need for O negative blood is the highest because it is used most often during emergencies. The need for O+ is high because it is the most frequently occurring blood type (37% of the population).
What is the most neutral blood type? ›
Rh-null or golden blood
It is the world's rarest blood type, with fewer than 50 known cases ever reported. When a person's blood lacks all 61 possible antigens, they are said to be Rh-null.
Glucosamine has been implicated in isolated case reports in causing clinically apparent liver injury, but the role of glucosamine as opposed to other herbal components or contaminants has not been shown, and liver injury due to glucosamine or chondroitin must be very rare if it occurs at all.
Which is better for arthritis collagen or glucosamine? ›Conclusion. In summary, collagen and glucosamine are both essential compounds for maintaining healthy joints, bones, and skin. While collagen provides structural support to the body's connective tissues, glucosamine plays a crucial role in the formation of healthy cartilage.
What are the negative side effects of glucosamine chondroitin? ›- nausea, diarrhea, constipation;
- stomach pain, gas, bloating;
- hair loss; or.
- puffy eyelids.
There is no recommended daily allowance for NAC, because unlike vitamins, it's not an essential nutrient. The dosage used to prevent radio contrast dye damage is 600 mg to 1200 mg every 12 hours for 48 hours.
What is the downside of NAC? ›NAC may raise levels of homocysteine, an amino acid that is associated with heart disease. Be sure to have your doctor check your homocysteine level if you are taking NAC. Very high doses (more than 7 grams) of cysteine may be toxic to human cells and may even lead to death.
How long should you take NAC supplement? ›Depending upon why you're taking NAC, you'll likely want to take a 600 mg capsule 2-3 times a day. It's important never to exceed the recommended dose. People who take N-acetyl-L-cysteine to support their immune health often will take it twice a day for 30 days.
What is the best vitamin for stiff joints? ›Glucosamine and chondroitin are two of the most commonly used supplements for arthritis. They're components of cartilage—the substance that cushions the joints. Research on these supplements has been mixed, in part because studies have used varying designs and supplement types.
What is the best over the counter joint supplement? ›Fish oil, SAM-e and curcumin are among the supplements with the best evidence to support them. The research on glucosamine and chondroitin, some of the most popular supplements for osteoarthritis, is mixed, but they may help with OA pain and stiffness.
What joint supplements should I avoid? ›For this reason, the Agency conducted an assessment to identify the potential risks associated with taking these products. As a result of its expertise, ANSES advises certain populations to avoid consuming food supplements based on glucosamine and/or chondroitin sulfate.
What foods are high in NAC? ›
- cruciferous vegetables, such as broccoli, cauliflower, Brussels sprouts, and bok choy.
- allium vegetables, such as garlic and onions.
- eggs.
- nuts.
- legumes.
- lean protein, such as fish, and chicken.
According to the FDA, since NAC was not widely used as a dietary supplement before its use as a drug, it is basically unlawful.
Does NAC deplete zinc? ›3.1. NAC Reduces the Cu and Zn Content of Cells and Modulates Glutathione Concentrations.
What supplements stop hair fall? ›“Vitamins are essential for healthy hair growth and may help in preventing hair shedding and thinning,” says Michele Green, M.D., a cosmetic dermatologist in New York. “The best vitamins for hair growth include B vitamins, vitamin D, vitamin E, zinc, biotin and iron.
What vitamins affect hair loss? ›Only riboflavin, biotin, folate, and vitamin B12 deficiencies have been associated with hair loss. Vitamin B2 (riboflavin) is a component of two important coenzymes: flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) [22].
What supplements cause hair thinning? ›Over-supplementation of certain nutrients, including selenium, Vitamin A, and Vitamin E, has actually been linked to hair loss [4,8–11].
Does NAC get rid of inflammation? ›N-acetylcysteine (NAC) is a powerful antioxidant and a scavenger of hydroxyl radicals. Recently, NAC has also been shown to have anti-inflammatory activities in tissues.
Which vitamin is anti-inflammatory? ›Vitamin A deficiency is one of the most profuse nutritional deficiencies worldwide. It is associated with increased susceptibility to infectious diseases in both man and animal models. Vitamin A also has a role as an anti-inflammatory agent.
What supplements help inflammation and joint pain? ›- Glucosamine. 1/12. This amino sugar is a natural part of the cartilage in your joints. ...
- Chondroitin. 2/12. ...
- Fish Oil/Omega-3s. 3/12. ...
- Methylsulfonylmethane (MSM) 4/12. ...
- Vitamin D. 5/12. ...
- Turmeric. 6/12. ...
- Borage Oil. 7/12. ...
- SAMe (S-adenosylmethionine) 8/12.
Chondroitin is believed to enhance the shock-absorbing properties of collagen and block enzymes that break down cartilage. Like glucosamine, this supplement is thought to help cartilage retain water, keep joints lubricated, and possibly reverse cartilage loss.
What type of glucosamine is best for joint pain? ›
Generally safe
Glucosamine sulfate might provide some pain relief for people with osteoarthritis. The supplement appears to be safe and might be a helpful option for people who can't take nonsteroidal anti-inflammatory drugs (NSAIDs). While study results are mixed, glucosamine sulfate might be worth a try.
To supplement glucosamine, take 300 – 500 mg, three times a day, for a total daily dose of 900 – 1,500 mg. The benefits of glucosamine are dose-dependent, and studies use up to 2,000 – 3,000 mg a day, taken in several doses.
What is the benefit of N-acetyl glucosamine? ›N-acetyl glucosamine is taken for osteoarthritis and inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease.
Is N-acetyl glucosamine safe? ›Glucosamine hydrochloride is possibly safe for most adults when used for up to 2 years. N-acetyl glucosamine is also possibly safe when used for up to 6 months. Glucosamine can cause some mild side effects including bloating, nausea, diarrhea, and constipation.
What does N-acetyl glucosamine do for your face? ›Because of its stimulation of hyaluronic acid synthesis, glucosamine has been shown to accelerate wound healing, improve skin hydration, and decrease wrinkles. In addition, as an inhibitor of tyrosinase activation, it inhibits melanin production and is useful in treatment of disorders of hyperpigmentation.
Is NAC good for osteoarthritis? ›These results suggest that mechanical stress promotes osteoarthritis development through several ROS-induced factors, and that osteoarthritis in those contexts can be ameliorated by NAC treatment.
Is n acetyl glucosamine safe for skin? ›The skin renewal, smoothing and brightening properties of N-Acetyl Glucosamine are similar to those of Alpha Hydroxy Acids. Even better, N-Acetyl Glucosamine is suitable for all skin types including hyper-sensitive skin.
What is the generic name for NAC supplement? ›Acetylcysteine is available under the following different brand names: N-acetylcysteine, and Mucomyst.
What is N-acetylgalactosamine a component of? ›N-Acetylglucosamine (GlcNAc) is a monosaccharide that usually polymerizes linearly through (1,4)-β-linkages. GlcNAc is the monomeric unit of the polymer chitin, the second most abundant carbohydrate after cellulose.
What is the difference between N-acetyl-D-glucosamine and N-acetylglucosamine? ›The key difference between N-acetyl-D-glucosamine and N-acetyl glucosamine is that N-acetyl-D-glucosamine is the D isomer of N-acetyl glucosamine, whereas N-acetyl glucosamine is an amide that occurs as a major component in the bacterial cell wall. N-acetyl glucosamine is an important amide compound.
Is N-acetylgalactosamine an antigen? ›
These are carbohydrate derivatives containing a hexose moiety in which the oxygen atom is replaced by an N-acyl group. N-Acetylgalactosamine is also classified as an amino sugar derivative of galactose. In humans GalNAc functions as the terminal carbohydrate forming the antigen of blood group A.
Where is N-acetylgalactosamine found? ›N-acetylgalactosamine-4-sulfatase (arylsulfatase B) is a 38–41-kDa monomer enzyme isolated from liver.
What are natural sources of N acetyl glucosamine? ›Composed of N-acetyl-D-glucosamine and D-glucosamine units (Fig. 2.1), this polymer can be obtained from different sources, such as animals (crustaceous, insects, and mollusks), microorganisms (yeasts and filamentous fungi), or algae [2–4].
What are natural sources of N-acetylglucosamine? ›N Acetyl Glucosamine is a simple sugar derivative of glucose, naturally occurring in the outer shells of some insects and shellfish. It is also found in large concentrations in the liver, small intestine, thyroid, endocrine and sebaceous glands.
Is N-acetyl-D-glucosamine an enzyme? ›N-acetyl-D-glucosamine kinase is an enzyme that in humans is encoded by the NAGK gene.
Is N-acetyl glucosamine anti-inflammatory? ›N-acetylglucosamine (GlcNAc), a glucosamine (GlcN) derivative, has been developed as an immunomodulatory and anti-inflammatory inexpensive and non-toxic drug for non-communicable disease treatment and/or prevention.
Which is better glucosamine or glucosamine chondroitin? ›Studies have also differed on which of these supplements offers the greatest benefit for OA. Some find chondroitin to be superior, others favor glucosamine, while still others prefer a combination of the two. “Evidence would favor the two,” D'Adamo says. “They're typically bundled that way when you buy them.”
What blood type has antigen proteins? ›blood group A – has A antigens on the red blood cells with anti-B antibodies in the plasma. blood group B – has B antigens with anti-A antibodies in the plasma. blood group O – has no antigens, but both anti-A and anti-B antibodies in the plasma. blood group AB – has both A and B antigens, but no antibodies.
Where is GalNAc found? ›Core 2 O-GalNAc glycans are found in both glycoproteins and mucins from a variety of cells and tissues. Linear core 3 and branched core 4 O-GalNAc glycans (Table 9.1, Figure 9.2) have been found only in secreted mucins of certain mucin-secreting tissues, such as bronchi, colon, and salivary glands.
Which lectin is used in blood banking to determine a1 cells? ›Routine Use of Lectins in Blood Banking
Anti-A1 lectin obtained from Dolichos biflorus seeds are routinely used in blood banks to differentiate between A1 and A2 RBCs. This is especially important when the recipient is showing the presence of anti-A1 antibody active at physiological temperature.
Which of the following blood groups has N-acetylgalactosamine? ›
O blood group is the basic oligosaccharide structure for the different blood groups. It contains 2 galactose, a fucose and a N-acetylglucosamine.
Where is N Acetylmuramic acid found? ›N-Acetylmuramic acid (MurNAc) is part of the peptidoglycan polymer of bacterial cell walls.
Is N-acetylglucosamine present in cockroach? ›- The exoskeleton of cockroach is composed of chitin, which is a long-chain polymer of N-acetylglucosamine.