Are Enzymes Good for IBS? | casa de sante (2023)

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What are digestive enzymes? Do enzymes help with IBS? Which digestive enzymes work for IBS? So how can I use enzymes for IBS? You might want to check Low FODMAP Certified Digestive Enzymes Low FODMAP Certified Digestive Enzymes Vegan Protein Powder, Low FODMAP Certified, Gluten Free, Dairy Free, Soy Free, Grain Free, Sugar Free, All Natural, Non GMO, Low Carb Vegan Protein Powder, Low FODMAP Certified, Gluten Free, Dairy Free, Soy Free, Grain Free, Sugar Free, All Natural, Non GMO, Low Carb Organic Low FODMAP Certified Spice Mix (Mexican/Taco Seasoning Mix)- No Onion No Garlic, Gluten Free, No Sodium, No Carb, Keto, Paleo, Kosher Organic Low FODMAP Certified Spice Mix (Mexican/Taco Seasoning Mix)- No Onion No Garlic, Gluten Free, No Sodium, No Carb, Keto, Paleo, Kosher Whey (WPI) Chocolate Low FODMAP Protein Powder, NO Gluten, Lactose, Soy, Sugar or Grain, Low Carb, All Natural, ProHydrolase 3X Protein Absorption Whey (WPI) Chocolate Low FODMAP Protein Powder, NO Gluten, Lactose, Soy, Sugar or Grain, Low Carb, All Natural, ProHydrolase 3X Protein Absorption Whey (WPI) Vanilla Low FODMAP Protein Powder, NO Gluten, Lactose, Soy, Sugar or Grain, Low Carb, All Natural, ProHydrolase 3X Protein Absorption Whey (WPI) Vanilla Low FODMAP Protein Powder, NO Gluten, Lactose, Soy, Sugar or Grain, Low Carb, All Natural, ProHydrolase 3X Protein Absorption Organic Low FODMAP Spice Mix (Adobo Seasoning) - No Onion No Garlic, Gluten Free, Low Sodium, No Carb, Keto, Paleo, Kosher Organic Low FODMAP Spice Mix (Adobo Seasoning) - No Onion No Garlic, Gluten Free, Low Sodium, No Carb, Keto, Paleo, Kosher Organic Low FODMAP Certified Spice Mix (Tuscan Herb ) - No Onion No Garlic, Gluten Free, AIP, No Sodium, No Carb, Keto, Paleo, Kosher Organic Low FODMAP Certified Spice Mix (Tuscan Herb ) - No Onion No Garlic, Gluten Free, AIP, No Sodium, No Carb, Keto, Paleo, Kosher FAQs Videos

Irritable Bowel Syndrome (IBS) affects around 10-20% of people in North America and Europe. If you have IBS, chances are that your medications aren’t working very well. This is something common in IBS patients, which is why many turn to alternative treatment methods like digestive enzymes.

In this article, we’ll take a look at whether digestive enzymes really work (in the light of science!).

What are digestive enzymes?

Digestive enzymes are proteins that break down large molecules in your diet to aid digestion. They were initially designed for people with pancreatic insufficiency because the pancreas produces most digestive enzymes in the body (although smaller amounts are produced by the salivary glands, stomach, and the small intestine too).

Types of digestive enzymes include:

  • Amylase — breaks starch into maltose
  • Protease — breaks protein into amino acids
  • Lipase — breaks down fat into its constituent fatty acids and glycerols
  • Pepsin — breaks down protein and activates other protein-breaking enzymes
  • Lactase — breaks down the milk sugar lactose into glucose and galactose

All of these enzymes break down a larger molecule which is difficult to digest (like lactose) into smaller molecules that can easily diffuse through your gut lining (like glucose and galactose).

People with pancreatic insufficiency lack these enzymes and can face uncomfortable abdominal symptoms and malnutrition. This is why digestive enzyme supplements were made — supplementing the body with the enzymes it lacks in the form of a pill or droplet can alleviate the symptoms of pancreatic insufficiency. But how do these help IBS patients if at all? Let’s find out.

Do enzymes help with IBS?

Digestive enzymes do help in patients with IBS. IBS patients are often sensitive to a class of food molecules called FODMAP. Other patients lack the enzyme lactase and can’t digest dairy products including milk, cheese, cream, and yogurt.

As undigested FODMAPs and lactose make their way to the large intestine, they are fermented by bacteria and cause gas accumulation. These substances are also osmotic, which means they increase the water content of the gut. Since IBS patients have heightened gut sensitivity, increased amounts of gas and water lead to uncomfortable symptoms like bloating, pain, and nausea.

Since digestive enzymes can break down FODMAPs and lactose and reduce their delivery to the large intestine, they can potentially reduce the symptoms of IBS.

Let’s take a look at what research says about digestive enzymes and IBS.

Which digestive enzymes work for IBS?

There are many digestive enzymes available in the market, but only two have been studied closely by scientists. These are lactase and alpha-galactosidase, which break lactose and galactooligosaccharide (GOS) respectively.

Lactose deficiency is relatively common in IBS patients, and in these patients, symptoms of lactose intolerance (diarrhea, bloating, and flatulence) are indeed improved by lactase supplements. However, lactase supplements are not effective at treating IBS alone. And this is very important to realize. IBS treatment is holistic and involves medication to treat diarrhea/constipation as well as lifestyle changes like regular exercise and a low-FODMAP diet.

Lactase supplements can serve as an adjunct to these treatments but not a replacement.

The case is similar for alpha-galactosidase. Interestingly, all humans naturally lack alpha-galactosidase. In healthy individuals, GOS (which are found in cashews, beans, soy milk (produced from soybeans), pistachios, and green peas) is fermented by bacteria in the large intestine. This leads to the production of gas and short-chain fatty acids, which are believed to benefit health.

However, since the digestive tract of IBS patients is in sort of an overdrive, excess gas from GOS fermentation leads to uncomfortable symptoms in these patients.

In this study conducted by Monash University, 31 IBS patients on a low-FODMAP diet (except for GOS) were studied. Some patients were given full-dose alpha-galactosidase supplementation, others half-dose, and still others placebo. Patients given full-dose supplementation showed reduced IBS symptoms.

Interestingly, half-dose supplementation did not improve IBS symptoms, emphasizing the need for sufficient enzyme doses for effectiveness.

So how can I use enzymes for IBS?

Before you decide to try a supplement, here are some principles to bear in mind. First, it’s always a good idea to consult a doctor or a dietitian before investing in a product. It’s especially important to review the dosage and ingredients of a supplement with an expert because as we’ve seen, insufficient doses make supplements ineffective. Plus, some supplements contain FODMAPs like polyols, which can make your IBS worse instead of better. These can be identified by an expert.

Second, digestive enzymes are not stand-alone treatments for IBS. They are best used as an adjunct to a low-FODMAP diet, after you’ve identified your sensitivities to lactose or GOS. The goal of digestive enzymes is to allow you to follow a relatively less strict low-FODMAP diet. This will help you consume dairy, which is essential for bone health.

Third, digestive enzymes don’t work for everyone. All IBS patients respond differently to enzyme supplements. It may be a good idea to try them but there’s no guarantee they will work.

Finally, digestive enzyme supplements are not controlled by the FDA. This means it’s important to do extensive research about the quality and efficacy of a supplement before investing in it. Our FODMAP Digestive Enzymes is a good choice because in addition to being high-quality, it breaks down all FODMAPs (instead of just one or two some other supplements target), reducing your chances of IBS symptoms significantly.

Medically Reviewed by Onikepe Adegbola, MD PhD

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FAQs

Should I take enzymes if I have IBS? ›

Because many people with IBS have problems digesting specific foods, it is possible that taking digestive enzyme supplements known to help the body digest these foods will reduce symptoms.

Can digestive enzymes cure IBS? ›

Because IBS has multiple causes, digestive enzymes alone are unlikely to resolve your IBS. But in some IBS cases, a lack or deficiency of particular digestive enzymes may contribute to your symptoms. For example, symptoms of lactose intolerance —which includes bloating, cramping, and diarrhea — mimic symptoms of IBS.

Which is better for IBS probiotics or digestive enzymes? ›

Choose digestive enzymes if you have specific food intolerances or one of the conditions associated with exocrine pancreatic insufficiency. Choose probiotics if you have IBS, SIBO, or other types of gut imbalance.

Do digestive enzymes help with gut issues? ›

Naturally occurring digestive enzymes are a vital part of your digestive system. Without them, your body can't break foods down so that nutrients can be fully absorbed. A lack of digestive enzymes can lead to a variety of gastrointestinal (GI) symptoms.

Which digestive enzyme is best IBS? ›

The research

Research suggests that alpha-galactosidase supplementation may reduce symptoms of IBS. Alpha-galactosidase breaks down galactooligosaccharide (GOS), which is found in foods like beans and cashews.

Who should avoid digestive enzymes? ›

1 - Digestive enzymes that break down carbohydrates into sugars are not recommended for diabetics, or pregnant/breastfeeding women. This is because taking them breaks down more carbohydrates into sugars than your body normally would; so, anyone at risk of blood sugar issues should take caution.

Is it OK to take digestive enzymes every day? ›

Taking too many digestive enzymes can lead to symptoms of digestive discomfort, including: Constipation. Diarrhea. Abdominal cramps.

How do I get rid of IBS permanently? ›

There isn't a cure for IBS. However, there is treatment that can help control your symptoms. An integrative approach may include: mind-body techniques; dietary changes, like the low FODMAP diet; nutritional supplements; over-the-counter and prescription medications; and physical activity and exercise.

Do digestive enzymes reduce inflammation? ›

Proteolytic enzymes have many important functions in the body, including helping break down food for energy, and are found in certain foods and supplements. Studies suggest that they can improve digestion, decrease inflammation, ease arthritis pain and possibly reduce symptoms related to IBS.

How do I know if I need digestive enzymes? ›

Symptoms of enzyme deficiency tend to first show up in the gut. That's why you typically see digestive issues with insufficient enzyme levels like bloating, gas, diarrhea, constipation, and undigested food in stools. If your body doesn't have enough digestive enzymes, it's unable to break down foods properly.

How long do digestive enzymes take to work? ›

How Long Does It Take for Digestive Enzymes to Work? As mentioned, it takes about ten minutes for digestive enzymes to reach the stomach and start working. This is why we recommend taking digestive enzyme supplements about ten minutes before each meal.

Is apple cider vinegar a digestive enzyme? ›

Apple cider vinegar is loaded with enzymes that aid in digestion. While you can take digestive enzymes as a supplement, drinking apple cider vinegar may offer similar benefits for less money.

Is it worth taking digestive enzymes? ›

A lack of digestive enzymes can lead to certain health conditions, and vice versa. Taking digestive enzyme supplements is currently recommended for people with specific digestive disorders, such as pancreatic insufficiency and lactose intolerance.

What are the cons of digestive enzymes? ›

Cons
  • Gastrointestinal cramping and/or diarrhea.
  • The possibility of esophageal perforation when very large doses are ingested. ...
  • Some individuals experience allergic and/or anaphylactic reactions (relatively rare)
Sep 3, 2014

Do enzymes help with gas and bloating? ›

Digestive enzyme supplements purportedly fix all sorts of abdominal symptoms, including bloating, gas, and bowel irregularity, as well as overall gut health. However, for most people, there's little evidence that they do any good.

What is a good gut bacteria for IBS? ›

Most probiotics used in IBS treatment fall under two main groups: Lactobacillus and Bifidobacterium. These probiotics are thought to assist the digestive system. Among other functions, they may strengthen the intestinal barrier, assist the immune system in removing harmful bacteria, and break down nutrients.

How can I improve my digestion with IBS? ›

Eat more fiber

To help your body get used to more fiber, add foods with fiber to your diet a little at a time. Too much fiber at once can cause gas, which can trigger IBS symptoms. Adding fiber to your diet slowly, by 2 to 3 grams a day, may help prevent gas and bloating. Fiber may improve constipation in IBS.

What are the side effects of digestive enzymes? ›

Side effects of digestive enzymes include:
  • nausea.
  • diarrhea.
  • abdominal cramping.
  • headache.
  • neck pain.
  • nasal congestion.
  • swelling of the legs and feet.
  • rash.

Do digestive enzymes affect gut bacteria? ›

Digestive enzymes help break down your food while probiotics support the health of the gut microbiome. Their relationship can rightly be called complementary. Both can support your body in combating bloating, supporting digestion, and strengthening the immune system. Taking them together may maximize their impact.

What conditions do stomach enzymes work best in? ›

For example, an enzyme in the stomach called pepsin breaks down proteins. If your stomach doesn't have enough acid, pepsin can't function optimally. Temperature: Enzymes work best when your body temperature is normal, about 98.6°F (37°C).

In what conditions do enzymes work worse? ›

Enzymes work best under certain conditions, and enzyme activity will slow down if conditions are not ideal. For example, your normal body temperature is 98.6°F (37°C), but if you have a fever and your temperature is above 104°F (40°C), some enzymes in your body can stop working, and you could get sick.

What time of day should I take digestive enzymes? ›

When is the best time to take enzymes? For digestive purposes, it's best to take enzymes near the beginning of the meal. The goal is to maximize the amount of time the enzymes have in contact with the food.

Can you take probiotics and digestive enzymes at the same time? ›

As probiotics and digestive enzymes are different things and perform different jobs, it is absolutely fine to take them together.

Can you overuse enzymes? ›

Unlike certain vitamins, minerals and herbs, there is no upper limit (or threshold) to the number of supplemental enzymes that can be consumed. The reason for this is that the body has an estimated 100 trillion cells, and any one of those cells could be using thousands of different enzymes every second.

What is the new medication for IBS? ›

The US Food and Drug Administration (FDA) has approved tenapanor (Ibsrela)—a 50 mg, twice daily oral pill—for the treatment of individuals with constipation-predominant irritable bowel syndrome (IBS-C), according to a press release issued by its manufacturer, Ardelyx.

What are the new treatments for IBS? ›

Rifaximin (marketed as Xifaxan by Salix Pharmaceuticals) is an antibiotic, and eluxadoline (marketed as Viberzi by Actavis) is an antagonist and agonist of the δ and µ opioid receptors, respectively. Eluxadoline has been approved as a first-line treatment for the condition.

How can I control my IBS without medication? ›

Some common at-home treatments for IBS include relaxation exercises, hypnotherapy, physical activity, dietary changes, applying heat, and consuming peppermint oil or other supplements (such as prebiotics and probiotics).

What heals intestinal inflammation? ›

Anti-inflammatory drugs are often the first step in the treatment of ulcerative colitis, typically for mild to moderate disease. Anti-inflammatories include aminosalicylates, such as mesalamine (Delzicol, Rowasa, others), balsalazide (Colazal) and olsalazine (Dipentum).

What are the benefits of taking enzymes pills? ›

If your body doesn't make enough enzymes, you may benefit from taking digestive enzyme supplements with your meals. These supplements can help you to break down foods easier, and, in doing so, reduce digestive symptoms like: Gas. Bloating.

Is it good to take digestive enzymes daily? ›

“Overall, a healthy person really doesn't need to take digestive enzyme supplements,” Denhard explains. “The best digestive enzymes are the ones our bodies make naturally, and they work best when you eat a whole food diet.”

Is it better to take digestive enzymes in the morning or evening? ›

When is the best time to take enzymes? For digestive purposes, it's best to take enzymes near the beginning of the meal. The goal is to maximize the amount of time the enzymes have in contact with the food.

How long does it take for digestive enzymes to work? ›

How Long Does It Take for Digestive Enzymes to Work? As mentioned, it takes about ten minutes for digestive enzymes to reach the stomach and start working. This is why we recommend taking digestive enzyme supplements about ten minutes before each meal.

Can I take probiotics and digestive enzymes together? ›

As probiotics and digestive enzymes are different things and perform different jobs, it is absolutely fine to take them together.

What is the fastest way to get rid of intestinal inflammation? ›

5 Ways to Reduce Inflammation and Take Control of Your Gut Health
  1. Eat an anti-inflammatory diet. Share on Pinterest. ...
  2. Try an elimination diet. ...
  3. Reduce your stress levels. ...
  4. Take probiotics. ...
  5. Ensure you're getting the right amount of nutrients. ...
  6. 5 of the Most Anti-Inflammatory Foods You Can Eat.
Jan 28, 2019

What is the best supplement for digestive inflammation? ›

Lately, the use of various supplementations containing probiotics, butyrate, phosphatidylcholine, lactoferrin, palmitoylethanolamide (PEA), silymarin, and omega 3 has been strongly suggested to patients suffering from inflammatory diseases [2].

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